Drug eruption
☆ I le 2022 Stiftung Warentest i'uga mai Siamani, o le fa'amalieina o tagata fa'atau i ModelDerm sa na'o sina maualalo ifo nai lo fa'atalanoaga telemedicine totogi.
Drug eruption o loʻo faʻaalia e ala i le afaina o le tino atoa.
References
O a'afiaga o le pa'u e mafua mai i vaila'au, e ta'ua o le pa'u o fualaau, e mafai i nisi taimi ona ogaoga. O nei fa'alavelave matuia, e ta'ua o le severe cutaneous adverse drug reactions (SCARs) , ua manatu e ono lamatia ai le ola. E aofia ai tulaga pei o Stevens-Johnson syndrome (SJS) , toxic epidermal necrolysis (TEN) , acute generalized exanthematous pustulosis (AGEP) , and drug reaction with eosinophilia and systemic symptoms (DRESS) . A'o le SCARs e seasea, e tusa ma le 2% o tagata mama'i i falema'i e o'o iai.
Adverse drug reactions involving the skin are commonly known as drug eruptions. Severe drug eruption may cause severe cutaneous adverse drug reactions (SCARs), which are considered to be fatal and life-threatening, including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), acute generalized exanthematous pustulosis (AGEP), and drug reaction with eosinophilia and systemic symptoms (DRESS). Although cases are relatively rare, approximately 2% of hospitalized patients are affected by SCARs.
Adverse drug reactions involving the skin are commonly known as drug eruptions. Severe drug eruption may cause severe cutaneous adverse drug reactions (SCARs), which are considered to be fatal and life-threatening, including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), acute generalized exanthematous pustulosis (AGEP), and drug reaction with eosinophilia and systemic symptoms (DRESS). Although cases are relatively rare, approximately 2% of hospitalized patients are affected by SCARs.
O se tamaitai e 31 tausaga le matua na asiasi atu i le matagaluega o dermatology ma se vaega mumu e le tiga i le pito i luga o lona vae taumatau. Na ia inuina se tasi fua o le doxycycline (100 mg) i le aso na muamua atu, ina ua maeʻa togafitiga leisa picosecond mo maʻila maʻila. I le tausaga na teʻa nei, na ia aʻafia ai se faʻafitauli faʻapena i le nofoaga lava e tasi ina ua uma ona ave le fua tutusa o le doxycycline post-laser treatment. E leai sona tala'aga fa'afoma'i iloga ma e leai nisi fa'ailoga, pei o le fiva, i le lotoifale po'o lona tino atoa.
A 31-year-old woman presented to the dermatology department with an asymptomatic erythematous patch on the dorsum of her right foot. She had taken 1 dose of doxycycline (100 mg) the previous day as empirical treatment after picosecond laser treatment for acne scars. She had had a similar episode the previous year on the same site, after taking the same dose of doxycycline after laser treatment. She had no notable medical history, and no other local or systemic symptoms, including fever.
A 31-year-old woman presented to the dermatology department with an asymptomatic erythematous patch on the dorsum of her right foot. She had taken 1 dose of doxycycline (100 mg) the previous day as empirical treatment after picosecond laser treatment for acne scars. She had had a similar episode the previous year on the same site, after taking the same dose of doxycycline after laser treatment. She had no notable medical history, and no other local or systemic symptoms, including fever.
Stevens-Johnson syndrome (SJS) ma le toxic epidermal necrolysis (TEN) o ni ituaiga e lua o le tuga o le pa'u, e ese mai isi tulaga o le pa'u e pei ole erythema multiforme major ma le staphylococcal scalded skin syndrome, faapea foi ma fualaau faasaina. SJS/TEN ose fa'alavelave fa'afuase'i ma ogaoga e mafua ai le salalau lautele o le pa'u ma le mucous membrane fa'aleagaina, e masani ona iai fa'ailoga fa'apitoa. I luga o le 80% o mataupu, o vailaʻau o le mafuaʻaga.
Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN) are variants of the same condition and are distinct from erythema multiforme major staphylococcal scalded skin syndrome, and other drug eruptions. Stevens-Johnson syndrome/toxic epidermal necrolysis is a rare, acute, serious, and potentially fatal skin reaction in which there are sheet-like skin and mucosal loss accompanied by systemic symptoms. Medications are causative in over 80% of cases.
Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN) are variants of the same condition and are distinct from erythema multiforme major staphylococcal scalded skin syndrome, and other drug eruptions. Stevens-Johnson syndrome/toxic epidermal necrolysis is a rare, acute, serious, and potentially fatal skin reaction in which there are sheet-like skin and mucosal loss accompanied by systemic symptoms. Medications are causative in over 80% of cases.
O le sasaina o fualaau faasaina e masani lava ona iloa mai tala'aga faafoma'i ma su'esu'ega ile falema'i. Ole su'ega ole pa'u, su'ega toto po'o su'ega fa'ama'i e mafai fo'i ona aoga.
O faʻataʻitaʻiga o vailaʻau masani e mafua ai le paʻu o vailaʻau faʻamaʻi ma isi vailaʻau faʻamaʻi, sulfa drugs, nonsteroidal anti-inflammatory drugs (NSAIDs), chemotherapy agents for malignancies, anticonvulsants ma psychotropic drugs.
○ Suiga ma Togafiti
Afai e maua lou fiva (si'itia le vevela o le tino), e tatau ona e su'e vave togafitiga faafoma'i. Ole vaila'au masalomia e tatau ona fa'agata (eg antibiotic, non-steroidal anti-inflammatory drugs). A'o le'i asiasi i le falema'i, o vaila'au fa'ama'i e pei o le cetirizine po'o le loratadine e mafai ona fesoasoani i le mageso ma le mageso.
#Cetirizine [Zytec]
#LevoCetirizine [Xyzal]
#Loratadine [Claritin]
Su'ega toto (CBC, LFT, faitau eosinophil)
O vaila'au fa'ama'i ma vaila'au fa'ama'i fa'atasi ma le talavai a le foma'i